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Analysis and Detection of Quality Factors of Virtual Welding Strength and Barrier Performance of Multi-chamber Bags
Multi-chamber infusion soft bags are currently categorized into two main types in the large-scale infusion industry: liquid-liquid multi-chamber bags and powder-liquid multi-chamber bags. These products contain different infusion drugs within a single package, separated into distinct chambers by virtual welding. This design ensures that the components remain isolated during production, storage, and transportation. During clinical use, the virtual weld is opened using external force, allowing the contents to mix. Once mixed, the resulting solution is typically unstable and cannot be stored for long periods, requiring immediate preparation for administration. This paper focuses on two critical quality factors: the performance of the virtual welding and the barrier properties of multi-chamber infusion soft bags.
Testing and analyzing the strength of the virtual weld is essential for ensuring both the safety and usability of the product. The sealing strength must be sufficient to maintain integrity during storage and transport, yet not so strong that it hinders ease of use in clinical settings. The effectiveness of the virtual seal depends primarily on three key parameters: temperature, time, and pressure during the sealing process. Manufacturers must carefully control these variables to achieve optimal performance. Labthink’s HST-H3 heat seal tester and XLW (PC) intelligent electronic tensile tester are widely used for evaluating this critical parameter. When testing finished multi-chamber bags, samples are cut directly from the weld area, and the test is automatically conducted after selecting the “heat seal strength†option on the XLW (PC). Additionally, to determine the ideal welding conditions, manufacturers often conduct experiments using the HST-H3 heat sealer in combination with the tensile testing machine, analyzing the effects of temperature, time, and pressure on the weld strength.
Barrier performance is another crucial factor affecting the quality of multi-chamber bags. Whether it's a liquid-liquid or powder-liquid configuration, these products require effective barriers to prevent the penetration of oxygen and water vapor. To achieve this, an inner protective layer is often used to block moisture and oxygen ingress. In addition, during the packaging process, nitrogen displacement machines are employed to replace the air inside the bag, further enhancing the barrier effect. Therefore, barrier property tests should include measurements of oxygen permeability, nitrogen permeability, and water vapor transmission rate. Labthink’s VAC-V series of differential pressure gas permeameters are specifically designed to perform these tests accurately.
The application of multi-chamber infusion bags represents a significant advancement in the functionality of infusion soft bags. As part of strict pharmaceutical packaging requirements, these products must meet rigorous testing standards, including tensile strength, elongation, heat seal strength, film puncture resistance, rubber stopper puncture force, and overall sealing performance. Labthink has been a trusted provider of testing instruments and services for the global pharmaceutical industry for many years. We are committed to offering high-quality solutions and look forward to expanding our collaboration with companies and institutions in the pharmaceutical sector. For more information, please contact Guo Sijia at gz@.