Proteomics research escorts human health

The liver is a "chemical plant" for the metabolism of various substances in the human body, a "power station" for energy conversion, and a "distribution center" for various important information regulation molecules of the body. According to the World Health Organization, among the 350 million hepatitis B virus carriers in the world, nearly 50% of China's total, and 1 million new liver cancer patients are added every year in the world, half of which occur in China. Hepatitis has become China's major disease, and liver cancer has become the second "killer" of malignant tumors in China. The annual direct medical expenses for hepatitis and liver diseases in China are as high as more than 100 billion yuan. Overcoming liver disease has become an important issue of imperative.

Scientists predict that "the 21st century is the era of life sciences and biotechnology. Proteomics research, as an important pillar of functional genomics, is at the forefront of life science research." Proteome is the executive body of life activities, basic research and application. Research, life sciences and pharmaceutical industries and bio-economic ties and bridges are extremely important and limited biological strategic resources. Proteomic research can not only realize the docking and confirmation with the genome, but also directly reveal the regularity and essential characteristics of life activities, the pathological mechanism of the occurrence and development of major human diseases, and can promote and promote the basic disciplines of life sciences as well as analytical science, information science and materials. The development of applied disciplines such as science. Therefore, scientists from all over the world are competing to participate in this research, and Chinese proteome research has also occupied a place in the world.

The Human Liver Proteome Project will conquer liver disease. Scientists from the Chinese Academy of Sciences, the Chinese Academy of Military Medical Sciences, Tsinghua University and other universities and research institutions have developed in-depth research in the field of proteomics for nearly 10 years. Platform and Protein Research Center. In the human protein program, Chinese scientists have undertaken 30% of research tasks and become the main force in promoting the project. The Chinese scientists led by Academician He Fuchu took the lead in proposing and promoting the International Human Liver Proteome Project, which has been highly recognized by international academic peers.

The Human Liver Proteome Project consists of nine research topics, led by Chinese scientists, and the specific research topics are the responsibility of different countries. The research topics undertaken by Chinese scientists include: the construction of human liver protein expression profiles, the establishment of human liver proteome interaction linkage maps and the establishment and application of anti-human liver tissue protein antibody libraries.

On October 26, Academician He Fuchu, who attended the 3rd International Proteome Congress, said in an interview that the Human Liver Proteome Project led by Chinese scientists will help humans conquer liver diseases that pose a great threat to health.

Academician He Fuchu used to describe the liver proteomics research with “destroying and fishing”, referring to the “panoramic” research strategy adopted by proteomics research, which is the use of progressive proteomic separation and analysis techniques, and the Nobel Prize-winning bio-mass spectrometry in 2002. And large scientific platforms such as bioinformatics technology, systematically and comprehensively discover and confirm the types, quantities, modes of existence, interactions, modification states, and subcellular localization of human proteomes from cells, tissues, and organs. The pathological state is "one net is exhausted."

The final goal of the Human Liver Proteome Project led by Academician He Fuchu is to reveal and confirm the proteome of the liver; to quantify and validate the genes encoded by the Human Genome Project at the protein level; to achieve the liver transcriptome, liver proteome , docking and integration of plasma proteome and human genome; revealing the overall level of human transcription and translation, cluster regulation; establishing liver “physiological group” and “pathological group”; breakthrough for prevention, diagnosis, treatment and new drug development of major liver diseases Provide an important scientific foundation. He Fuchu said that Chinese scientists actively advocate and work hard to promote the "Human Liver Proteome Project", which is based on the urgent need for prevention and treatment of liver diseases in China.

Scientists hope to analyze the functional significance of liver protein in physiological and pathological processes through human liver protein research, provide scientific basis for early warning, prevention, diagnosis and treatment of liver diseases, and bring great effects to the rapid development of national health and economy. .

Proteomics research can develop "blockbuster" new drug researchers found that most diseases in the human body are caused by mutation or destruction of the proteome, and most of the drugs work by affecting or repairing the proteome. Therefore, human proteomics research has far-reaching significance for directly revealing the laws and essences of life activities and discovering the laws governing the occurrence and development of major human diseases. Proteome plans are more complex than genome plans. Because there is only one map of the gene, the maps of the proteomes of different organs are different. This requires scientists from all over the world to unite and conduct research together.

"If the Human Genome Project is to send humans to the moon, then the proteome project will prompt humans to successfully return to Earth; if the Human Genome Project is a book full of the mysteries of human life, then the proteome project is to interpret this book. Method, the academician He Fuchu used the metaphor of the image to make proteomics easy to understand. He Fuchu said that protein as a gene product is the main bearer and performer of life activities. The implementation of the Human Genome Project has enabled the scientific community to use large-scale genomic research methods and results to develop, evaluate, and explore new models for the effectiveness, targeting, and safety of clinical drugs. This is what Zui has proposed in recent years. "Pharmacogenomics." Since the Human Genome Project does not reveal the entire secret of human life and death as a result of surpassing the protein's executive function of the biological function, pharmacogenomics must also borrow the academic achievements of proteomics.

According to Academician He Fuchu, scientists hope to analyze the functional significance of liver protein in physiological and pathological processes through the panoramic, high-throughput and large-scale research of human liver protein, and provide scientific basis for early warning, prevention, diagnosis and treatment of liver diseases. To make a major contribution to the conquest of liver disease. Scientists predict that the implementation and completion of the Human Liver Proteome Project will find a large number of important functional proteins, discover new drug targets, and develop a number of "blockbuster" new drugs, antibodies and diagnostic products for the nationals. The rapid development of health and economy has a huge impact.

Global scientists scramble to explore the "key of life"

"In today's world, whoever has mastered the enormous number of tools in the Human Antibody Group Project, who has mastered the key to life sciences." This is a summary of the importance of life scientists for proteomics research, and Chinese life scientists also express here. "China has the conditions and the ability to lead the world into this new field. The completion of the Human Antibody Group Program will put China at the forefront of world science."

Professor Li Jianxun, a life scientist and chairman of the Proteintech Group of the United States, said that the Human Genome Project has successfully opened the door to exploring the door to life, and the human proteome project came into being. How to use this new technology field to create vitality for China's life sciences has become a major issue. An effective tool for studying human proteome Zui is antibodies. Professor Li Jianxun pointed out that antibody research has great economic benefits. In all biomedical fields, there are tens of billions of dollars in demand for antibodies every year. At present, China has a foreign market brought by “sea turtles”. It has a good investment environment and a high-tech and low-cost university talent team. The human and cost of the Western countries are at a disadvantage. Our "low cost" has also changed Western scientific research methods.

Experts believe that the current launch of the Human Proteome Project on a global scale is an inevitable choice for scientific development. As the "executor" of life activities, protein has naturally become the focus of new research. Proteomics, which is characterized by the study of a complete set of proteins possessed by a cell, tissue or whole organism, naturally becomes the "mainstay" in functional genomics and constitutes the strategic high ground of functional genomics research.

Academician He Fuchu, Executive Chairman of the World Proteome Organization, pointed out that the "Third International Proteome Congress" held in China on October 26th, in addition to promoting China's research in the field of proteomics, another important purpose is to hope to have important practices for China. The significance of liver proteomics research has pushed to a new climax, seeking a more convenient way to solve liver diseases that seriously threaten the health of our population.

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