Pharmaceutical Grade Raw Materials Promethazine HCl for Allergic Disorders

Model NO.: 99%
CAS: 58-33-3
Trademark: TJ
Transport Package: Camouflage Package
Specification: White powder
Origin: China
HS Code: 2937230090
Model NO.: 99%
CAS: 58-33-3
Trademark: TJ
Transport Package: Camouflage Package
Specification: White powder
Origin: China
HS Code: 2937230090

Pharmaceutical Grade Raw Materials Promethazine HCL For Allergic Disorders

Product Details:

Product Name Promethazine hydrochlorine
Other Name Promethazine HCl
Chemcial Name N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
CAS 58-33-3
MF C17H21ClN2S
MW 320.88
EINECS 200-375-2
Assay 99.8%
Appearence White powder
urpose

This product is used for skin and mucosa irritation, allergic rhinitis,

asthma, food allergies, skin scratch disease, motion sickness, airsickness etc..


Description:
Promethazine hydrochloride is a phenothiazine used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. Promethazine injection is usually given when a person cannot take the medication orally (by mouth). Promethazine hydrochloride is available in generic form. Promethazine hydrochloride suppositories (Brand Names: Phenadoz, Promethegan) is a phenothiazine that works by changing the actions of chemicals in your brain, and also acts as an antihistamine, used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Promethazine hydrochloride suppositories is also used to prevent motion sickness, treat nausea and vomiting or pain after surgery, and as a sedative or sleep aid. Promethazine hydrochloride suppositories are available in generic form. Common side effects of promethazine hydrochloride suppositories include dizziness, drowsiness, sleepiness, restlessness, blurred vision, dry mouth, stuffy nose, ringing in the ears, weight gain, swelling in hands or feet, impotence, trouble having an orgasm, or constipation.

Application:
Antihistaminic, antiemetic, CNS depressant
stool softener
With aminophylline in the treatment of asthma
For the treatment of allergic disorders, and nausea/vomiting.
Dubbed hibernation and injection for artificial hibernation.
Perennial and seasonal allergic rhinitis
Vasomotor rhinitis.
Allergic conjunctivitis due to inhalant allergens and foods.
Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
Amelioration of allergic reactions to blood or plasma.
Dermographism.
Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled.
Preoperative, postoperative, or obstetric sedation.
Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
Therapy adjunctive to meperidine or other analgesics for control of postoperative pain.
Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.
Active and prophylactic treatment of motion sickness.
Antiemetic therapy in postoperative patients.

The dose of promethazine depends on the condition being treated. Typical doses range from 12.5 mg to 25 mg, and may be taken once daily or several times per day, as prescribed. Promethazine may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor, medicines to treat stomach ulcer or irritable bowel syndrome. Many other medicines can interact with promethazine. Tell your doctor all medications and supplements you use. During pregnancy, promethazine should be used only if prescribed. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Pharmaceutical Grade Raw Materials Promethazine HCl for Allergic Disorders


COA:

Items of analysis Specification Results
description a white or faintly yellowish,crystalline powder a white crystalline powder
solubility very soluble in water,freely soluble in chloroform and in ethanol(95%),practically insoluble in ether very soluble in water,freely soluble in chloroform and in ethanol(95%);practically insoluble in ether
identification    
A. IR absorption spectrum the positions and relative sizes of the banks in the spectrum of the sample and reference spectrum shall be concordant the positions and relative sizes of the bands in the spectrum of the sample and reference spectrum are concordant
B.by TLC It complies with the identification test for phenothiazines it complies with the identification test for phenothiazine
C.Test with nitric acid forms orange colored solution and organge-red precipitate forms orange colored solution and organge-red precipitate
D.test for chlorides shall comply the test complies with test for chlorides
pH(10% w/v solution) 4.0-5.0 4.31
related substances(by TLC)    
isopromethazine not more than 1.0% less than 1.0%
other impurity not more than 0.5% less than 0.5%
sulphated ash not more than 0.5% 0.20%
loss on drying at 105ºC not more than 0.5% 0.20%
assay(by potentiometric titration) 98.5-101%(on anhydrous basis) 100.0%
Conclusion Qualified

Our adwantage:
1, High quality with competitive price:
    1) Standard: Enterprise Standard
    2) All Purity≥98%
    3) We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
    1) Parcel can be sent out within 24 hours after payment. Tracking number available
    2) Secure and discreet shipment. Various transportation methods for your choice.
    3) Customs pass rate ≥99%
    4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and      we have stock in there for transferring.

3, We have clients throughout the world.
    1) Professional service and rich experience make customers feel at ease, adequate stock and fast                delivery meet their desire.
    2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our            responsibility.
    3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the                customers.

Pharmaceutical Grade Raw Materials Promethazine HCl for Allergic Disorders
 

Pharmaceutical Grade Raw Materials Promethazine HCL For Allergic Disorders

Product Details:

Product Name Promethazine hydrochlorine
Other Name Promethazine HCl
Chemcial Name N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
CAS 58-33-3
MF C17H21ClN2S
MW 320.88
EINECS 200-375-2
Assay 99.8%
Appearence White powder
urpose

This product is used for skin and mucosa irritation, allergic rhinitis,

asthma, food allergies, skin scratch disease, motion sickness, airsickness etc..


Description:
Promethazine hydrochloride is a phenothiazine used to treat or prevent nausea and vomiting caused by anesthesia or surgery, certain types of allergic reactions, pain caused by surgery or childbirth, and to sedate patients before surgery or medical procedures. Promethazine injection is usually given when a person cannot take the medication orally (by mouth). Promethazine hydrochloride is available in generic form. Promethazine hydrochloride suppositories (Brand Names: Phenadoz, Promethegan) is a phenothiazine that works by changing the actions of chemicals in your brain, and also acts as an antihistamine, used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Promethazine hydrochloride suppositories is also used to prevent motion sickness, treat nausea and vomiting or pain after surgery, and as a sedative or sleep aid. Promethazine hydrochloride suppositories are available in generic form. Common side effects of promethazine hydrochloride suppositories include dizziness, drowsiness, sleepiness, restlessness, blurred vision, dry mouth, stuffy nose, ringing in the ears, weight gain, swelling in hands or feet, impotence, trouble having an orgasm, or constipation.

Application:
Antihistaminic, antiemetic, CNS depressant
stool softener
With aminophylline in the treatment of asthma
For the treatment of allergic disorders, and nausea/vomiting.
Dubbed hibernation and injection for artificial hibernation.
Perennial and seasonal allergic rhinitis
Vasomotor rhinitis.
Allergic conjunctivitis due to inhalant allergens and foods.
Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
Amelioration of allergic reactions to blood or plasma.
Dermographism.
Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled.
Preoperative, postoperative, or obstetric sedation.
Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
Therapy adjunctive to meperidine or other analgesics for control of postoperative pain.
Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.
Active and prophylactic treatment of motion sickness.
Antiemetic therapy in postoperative patients.

The dose of promethazine depends on the condition being treated. Typical doses range from 12.5 mg to 25 mg, and may be taken once daily or several times per day, as prescribed. Promethazine may interact with cold or allergy medicine, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression, lithium, atropine, belladonna, benztropine, dimenhydrinate, methscopolamine, scopolamine, blood pressure medications, blood thinners, bronchodilators, bladder or urinary medications, MAO inhibitors, medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor, medicines to treat stomach ulcer or irritable bowel syndrome. Many other medicines can interact with promethazine. Tell your doctor all medications and supplements you use. During pregnancy, promethazine should be used only if prescribed. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Pharmaceutical Grade Raw Materials Promethazine HCl for Allergic Disorders


COA:

Items of analysis Specification Results
description a white or faintly yellowish,crystalline powder a white crystalline powder
solubility very soluble in water,freely soluble in chloroform and in ethanol(95%),practically insoluble in ether very soluble in water,freely soluble in chloroform and in ethanol(95%);practically insoluble in ether
identification    
A. IR absorption spectrum the positions and relative sizes of the banks in the spectrum of the sample and reference spectrum shall be concordant the positions and relative sizes of the bands in the spectrum of the sample and reference spectrum are concordant
B.by TLC It complies with the identification test for phenothiazines it complies with the identification test for phenothiazine
C.Test with nitric acid forms orange colored solution and organge-red precipitate forms orange colored solution and organge-red precipitate
D.test for chlorides shall comply the test complies with test for chlorides
pH(10% w/v solution) 4.0-5.0 4.31
related substances(by TLC)    
isopromethazine not more than 1.0% less than 1.0%
other impurity not more than 0.5% less than 0.5%
sulphated ash not more than 0.5% 0.20%
loss on drying at 105ºC not more than 0.5% 0.20%
assay(by potentiometric titration) 98.5-101%(on anhydrous basis) 100.0%
Conclusion Qualified

Our adwantage:
1, High quality with competitive price:
    1) Standard: Enterprise Standard
    2) All Purity≥98%
    3) We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery
    1) Parcel can be sent out within 24 hours after payment. Tracking number available
    2) Secure and discreet shipment. Various transportation methods for your choice.
    3) Customs pass rate ≥99%
    4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and      we have stock in there for transferring.

3, We have clients throughout the world.
    1) Professional service and rich experience make customers feel at ease, adequate stock and fast                delivery meet their desire.
    2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our            responsibility.
    3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the                customers.

Pharmaceutical Grade Raw Materials Promethazine HCl for Allergic Disorders
 

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