Nosiheptide Feed Additives,Nosiheptide Antibiotics,Nosiheptide Growth Prompter,Nosiheptide Poultry Shandong Shengli Bioengineering Co., Ltd , https://www.shenglipharm.com
Correct understanding of feed additives probiotics
Probiotics are compound biological preparations that have been purified, purified, and dried by the use of animal beneficial microorganisms approved by the Ministry of Agriculture. They are ideal green additives for reducing or replacing antibiotics. Probiotic, also known as probiotics or live bacteria, is a type of active microbial additive. The benefits of probiotics on health status and performance are most effective in piglets because piglets have not yet established a stable gut microflora. In addition, when piglets use antibiotics for disease treatment, intestinal microbes are usually killed in large numbers. Therefore, taking probiotics after antibiotic treatment is beneficial to the reconstruction of beneficial gut microflora in animals, which can prevent the host from recurring pathogenic colonization. How probiotics work 1. Competitive exclusion The concept of competitive exclusion refers to the addition of a culture of selected beneficial microorganisms to the feed, competing with potentially harmful bacteria for adhesion sites and organic matrices (mainly carbon and energy). Probiotics colonize and multiply in the gastrointestinal tract, preventing the adhesion of other bacteria, including harmful strains such as E. coli (E. coli) or Salmonella. Undoubtedly, probiotics potentially reduce the risk of infection and intestinal disorders. 2. Bacterial-resistant probiotic microorganisms, once established in the intestine, produce bactericidal substances or bacteriostatic substances (bacteriocins) such as lactoferrin, lysozyme, hydrogen peroxide and several organic substances. These substances have a detrimental effect on harmful bacteria, which is mainly due to a decrease in intestinal pH (Kelly and King, 2001, Conway, 1996). The decrease in pH partially compensated for the lack of gastric acid secretion in weaned piglets. In addition, competition between probiotics and other bacterial energy and nutrients inhibits the growth of pathogens (Ewing and Cole, 1994). Correct understanding of probiotics probiotics for disease, lies in prevention rather than treatment; it can maximize the potential of animal production, but for some feed, its preparation level has been high, the role of adding probiotics can not be shown; The theory of intestinal flora balance applies to any animal, which is also the reason for the wide range of applications of probiotics, but it does not mean that it can "encourage all diseases." Since strains are host-derived, strains isolated from pig intestine have significant effects on pigs and may not be effective on chickens, because probiotic products that are formed from different strains must have the most suitable target. In general, the following aspects should be noted. 1. Because the intestinal flora is not established or in a state of constant change in the primary animals, the use of probiotics during this period is more effective than the establishment of relatively stable flora after the late growth period. 2. The effect of the presence of bacterial flora in the host's intestine is lacking in the presence of beneficial bacteria or the presence of counteracting bacteria (ie, growth-inhibiting bacteria) in the intestine. Otherwise, if the animal is naturally inoculated with a large number of beneficial bacteria or no counteracting bacteria exist, the effect is not obvious. Therefore, the effect is most obvious under poor conditions. 3. Prebiotics should be used continuously. Because of the periodic variation in serotypes among probiotic strains, the persistence of strains remaining in the intestine depends on their ability to compete for intestinal mucosal binding sites. 4. There are also differences in the probiotics required for animals of different growth stages. For mammals, the diet before and after weaning is different, the nutrients in the intestine are different, and the required probiotics are also different. Therefore, special applicable probiotics should be supplied to different animals. 5. Research at home and abroad has shown that the use of probiotics in low-level diets is more effective than nutritionally more comprehensive full-price diets. 6. When applying probiotics, care should be taken to determine the presence and amount of antibiotics in the diet. - On the other hand, although some probiotic strains have a certain degree of tolerance or produce some bacteriocins, the vast majority of strains used are sensitive to antibiotics. Even a small amount of bacteriocin is a form of self-protection mechanism in the organism. On the other hand, the dose of sub-therapeutic antibiotics used in formulated feeds far exceeds the tolerated dose of probiotics. 7. The use of probiotics in animals primarily serves to prevent and promote growth, and treatment is not as rapid as antibiotics.